Table 1.

Principles suggested and scored by participants

Principle	Cumulative score
Enable valid comparisons between cohorts	33
Subject to scientific validation	33
Achieve high intra- and inter-rater reliability	32
User-friendly and easy to apply	30
Include several relevant regions of brain	29
Should not require specialised equipment	29
Record association with other pathological findings	25
Avoid prior assumptions about biological relevance of CAA (i.e. avoid assessing severity according to the absence of presence of findings such as infarcts or haemorrhage)	25
Assessment of CAA based on labelling with antibodies	24
Highly sensitive to detection of mild CAA	22
Relate score to clinical as well as pathological features	19
Based on same blocks as used for CERAD assessment	18
Demonstrate amyloid nature of vascular deposits, in addition to Aβ on immunohistochemistry	15