Table 8.
Relationship between APOE ε2, CAA and vasculopathy in control and AD brains
| Unadj p | OR | 95% CI (OR) | p | ||
|---|---|---|---|---|---|
| All | pCAA | 0.001 | 4.38 | (2.45-7.80) | <0.001*** |
| mCAA | 0.001 | 10.93 | (4.33-27.57) | <0.001*** | |
| capCAA | 0.160 | 2.91 | (1.10-7.66) | 0.031* | |
| vasculopathy | 0.255 | 0.52 | (0.13-2.09) | 0.357 | |
| Frontal | pCAA | 0.019 | 3.93 | (2.11-7.30) | <0.001*** |
| mCAA | 0.010 | 5.74 | (2.89-11.38) | <0.001*** | |
| capCAA | 0.288 | 1.69 | (0.55-5.24) | 0.361 | |
| vasculopathy | 0.359 | 0.37 | (0.05-3.02) | 0.352 | |
| Temporal | pCAA | <0.001 | 5.11 | (2.64-9.89) | <0.001*** |
| mCAA | 0.001 | 9.88 | (3.56-27.43) | <0.001*** | |
| capCAA | 0.504 | 2.71 | (0.77-9.60) | 0.121 | |
| vasculopathy | 0.556 | 2.20 | (0.56-8.68) | 0.257 | |
| Parietal | pCAA | 0.002 | 3.28 | (1.77-6.08) | <0.001*** |
| mCAA | <0.001 | 6.56 | (2.32-18.59) | <0.001*** | |
| capCAA | 0.004 | 5.69 | (1.70-18.99) | 0.005** | |
| vasculopathy | 0.649 | 0.40 | (0.05-3.09) | 0.376 | |
| Occipital | pCAA | 0.001 | 3.15 | (1.49-6.68) | 0.003** |
| mCAA | 0.007 | 7.16 | (2.31-22.13) | <0.001*** | |
| capCAA | 0.381 | 1.23 | (0.41-3.70) | 0.714 | |
| vasculopathy | 0.152 | 1.48 | (0.27-8.24) | 0.654 |
Significance at
*
p<0.05;
significance at
**
p<0.01;
significance at
***
p<0.001.