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. 2014 Mar 28;7:4. doi: 10.1186/1755-1536-7-4

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Copyright © 2014 Genovese et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Neo-epitope markers for ECM remodelling. a) Neo-epitopes of collagen type I generated by different post-translational modifications provide more information than the measurement of total collagen type I. b) Formation of detectable neo-epitopes generated by cleavage of ECM proteins by specific proteases. ECM, extracellular matrix.