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. 2014 Mar 29;7:21. doi: 10.1186/1756-6606-7-21

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Copyright © 2014 Onouchi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Increased locomotor activity in open field test in Apc^1638T/1638Tmice. (A) Distances traveled (genotype effect, F_1,41 = 22.58, p < 0.0001; genotype × time interaction, F_23,943 = 2.909, p < 0.0001), (B) time spent in the center of the compartment (genotype effect, F_1,41 = 18.699, p < 0.0001; genotype × time interaction, F_23,943 = 1.664, p = 0.0258), (C) counts of stereotypic behavior (genotype effect, F_1,41 = 41.58, p < 0.0001; genotype × time interaction, F_23,943 = 5.233, p < 0.0001), and (D) counts of vertical activity were recorded. The p values in the figure indicate genotype effect in two-way repeated measures ANOVA. Error bars indicate SEM.