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. 2014 Apr 15;4:4689. doi: 10.1038/srep04689

Figure 2. Phenotypic variations observed in the progeny of TOY-KO mice.

Figure 2

(a) The hydrocephalus trait was transmitted to the next generation in the TOY-KO pedigree. A hematoxylin/eosin-stained section showing the typical features of the hydrocephalus trait. Blue indicates a mouse with hydrocephalus, and green indicates a mouse carrying the causative mutation without the hydrocephalus phenotype (also shown in Supplementary Fig. S2 online). (b) Hydrocephalus. MRI, hematoxylin/eosin staining and X-ray images of normal (C57BL/6J) and hydrocephalus TOY-KO mice are shown in the upper panel. MRI images were obtained using an MRI mini SA (DS Pharma Biomedical Co. Ltd., Suita, Japan). X-ray images were obtained using a μFX-1000 (Fuji Photo File Co. Ltd.). (c) Pedigrees of the TOY-KO mouse mated with C57BL/6J (shown as B6) and 129Sv mice are shown in the lower panel. Blue indicates a mouse with hydrocephalus, and green indicates a mouse carrying the causative mutation without the hydrocephalus phenotype.