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. 2014 Apr 15;4:4689. doi: 10.1038/srep04689

Figure 3. Identification of de novo germline mutations in TOY-KO mice.

Figure 3

(a) Scheme for screening of germline mutations. (b) Pedigree of TOY-KO mice used for germline mutation analysis. TOY365F, TOY609F and TOY450F were used to identify de novo germline mutations. Blue numbers, 84, 98, and 114, indicate the number of mutations detected in TOY365F, TOY609F and TOY450F, respectively. Numbers in parentheses indicate the number of original mutations in each generation, which were found in tail DNA for the first time in the pedigree. The DNA of TOY110F was unavailable; therefore, the mouse was excluded from the analysis. (c) The numbers of base substitution mutations found in TOY365F, TOY609F and TOY450F.