Table 3.
Pulmonary physiologic results in the placebo versus albuterol groups
Placebo (N = 246) | Albuterol (N = 260) | Treatment effect on markers |
|||||
---|---|---|---|---|---|---|---|
Variable | Baseline | End of Study |
P1 | Baseline | End of Study |
P1 | P2 |
PaO2/FiO2 ratio (mmHg) | 317 ± 146 | 369 ± 135 | <0.001 | 312 ± 150 | 367 ± 138 | <0.001 | 0.98 |
A-a gradient (mmHg) | 283 ± 162 | 247 ± 145 | <0.001 | 297 ± 169 | 256 ± 145 | <0.001 | 0.75 |
Plateau pressure (cm H2O) | 20.4 ± 4.4 | 19.7 ± 5.1 | 0.032 | 21.1 ± 4.9 | 20.3 ± 4.1 | 0.002 | 0.43 |
Tidal volume (ml) | 703 ± 132 | 718 ± 135 | 0.022 | 688 ± 126 | 718 ± 130 | <0.001 | 0.20 |
Positive end expiratory pressure (cmH2O) | 5.70 ± 1.86 | 5.73 ± 1.88 | 0.82 | 5.91 ± 2.19 | 5.82 ± 1.88 | 0.51 | 0.88 |
Static compliance of the respiratory system (ml/cmH2O) | 50 ± 15 | 56 ± 38 | 0.018 | 48 ± 14 | 52 ± 14 | <0.001 | 0.14 |
Total chest radiographic score | 4.6 ± 3.2 | 4.4 ± 2.8 | 0.19 | 4.7 ± 3.3 | 5.0 ± 3.2 | 0.39 | 0.035 |
Data as mean ± SD,
Paired t-test,
Analysis of covariance (ANCOVA)