. Author manuscript; available in PMC: 2014 Apr 15.

Published in final edited form as: Nat Rev Cancer. 2013 Jul 11;13(8):585–595. doi: 10.1038/nrc3556

Table 2.

Sequence specific DNA elements bound by mammalian MuvB-containing complexes.

DNA Sequence Element	Primary Sequence Consensus	Transcription Factor	Examples of Target Genes
Cell cycle genes Homology Region (CHR)^{38, 39}	5’-TTTGAA-3’	LIN54 / MuvB core	CDC2, PLK1, AURKB, CKS1
Downstream Repression Site (DRS)⁴⁰	5’-GGAAA-3’	p130/p107, E2F	MYBL2
Cell cycle Dependent Element (CDE)³⁷	5’-E2F site-NNNNCHR-3’	E2F?	CDC2, AURKB, CKS1
E2F site ^{136, 137}	5’-TTTSSCGC-3’ (S=G or C)	Heterodimers of E2F1/2/3 or E2F4/5 with DP1/2	PCNA, CDC6, POLA, E2F1
Myb-Recognition element (MRE)^{81, 138, 139}	5’-YAACKG-3’ (K=G or T)	AMYB, BMYB and MYB	CCNB1, CDC2, BIRC5
FOXM1 binding sequence¹⁴⁰	5’-TAAACA-3’	FOXM1	CKS1, AURKB, CENPA