Table 5.
Networks generated from endometrial gene expression data of HF versus LF heifers by IPA
| Network ID | Top functions | Molecules in network | Score | Focus molecules |
|---|---|---|---|---|
| 1 | Lipid Metabolism, Small Molecule Biochemistry | ACTB, ADCY2, ADCY3, ANXA6, ARHGDIG, CACNB2, Calmodulin, CNOT8, CTSL2, ERK, F Actin, FAU, FKBP7, FKBP10, FLNC, FSH, GJA1, GUCY, hCG, IFI6, IL33, Lh, MARCKS (includes EG:4082), NPPC, NR0B1, NTN4, Peptidylprolyl isomerase, PHLDA1, Pkc(s), PPIH, Rock, RPLP1, RPLP2, SRD5A1, TP53I11 | 45 | 25 |
| 2 | Cellular Growth and Proliferation, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function | ACTA2, Alpha Actinin, CAT, CIAO1, COL1A2, Collagen type I, Collagen(s), COPB2, CSRP1, CSRP2, CXCL2, ENPP1, FERMT2, FHL2, FHL3, FST, G-Actin, GADD45B, GEFT, HSPB1, Integrin, Laminin, LTBP1, MAGED1, MMP19, MYLK, NFkB (complex), Pak, Pdgf, PJA1, RARRES2, RIT1, SERPINH1, Tgf beta, TGFB1I1 | 45 | 25 |
| 3 | Carbohydrate Metabolism, Haematological Disease, Metabolic Disease | 26 s Proteasome, Akt, AMPK, EIF2C4, ELOVL5, FASN, GLUL, HISTONE, Histone h3, Histone h4, HMG20B, Hsp90, MAP3K7IP2, MED13, MED27, N-cor, ODC1, PPARA, PSMB10, PSMD2, PSMD11, PTPRK, RAB3B, RBBP7, RCAN2, RPL23, RPS3, RPS5, SFRP1, SMOC2, SOX6, SRPK2, T3-TR-RXR, Ubiquitin, UCP3 | 44 | 25 |
| 4 | Cell Death, Gene Expression, Lipid Metabolism | ACAT1, Caspase, CD58, CMPK1, ERK1/2, FUS, HMGB1 (includes EG:3146), IFN Beta, IgG, IL1, IL12 (complex), IL6ST, ILF3, IMPDH2, Insulin, Interferon alpha, Jnk, LDL, LGALS1, LGALS3, LRAT, Mapk, Mek, NES, P38 MAPK, PCCB, PDGF BB, PI3K, PIBF1, PRMT1, RABEP1, Ras, SLC25A12, STAT5a/b, TNIK | 28 | 18 |
| 5 | Cell Morphology, Inflammatory Response, Lipid Metabolism | ARHGDIG, ARHGEF, ARHGEF11, CPS1, EMP3, ETFDH, FAU, FNBP1, GLI3, IFI6, LARP1, LEP, Lpa receptor, P2RX7, Pka, PLXNB2, PXN, RAGE, Ras homolog, RCN3, RGNEF, RHOH, RHOU, RHPN1, RND2, RPL8, RPL26, RPL29 (includes EG:6159), RPLP2, SCAMP2, St3gal, ST3GAL3, TNF, UCP3, YWHAZ | 27 | 17 |
| 6 | Drug Metabolism, Small Molecule Biochemistry, Cell-To-Cell Signalling and Interaction | ABHD5, ALDH3A2, BAG3, BCL2, beta-estradiol, BIK, BOC, C1QTNF6, CDON, CTNNB1, CTSH, CXADR, EEF2, F12, FOLH1, GADD45B, GIMAP5, HOXC6, HSPB8, IFT122, IGFBP6, KCNMB1, METTL7A, MME, MRVI1, PLIN2, PLIN5, PNPLA2, PTGIS, PTPRK, PTPRU, SEMA5A, SFRP1, SULT1A1, SULT1A3 | 25 | 17 |
| 7 | Embryonic Development, Organ Development, Organ Morphology | Arginase, AZGP1, BMP6, C12ORF11, C19ORF10, C21ORF7, CALM2, COL16A1, COL4A6, CSRP2, CTSH, CTSL2, DBNDD2, DPYSL3, DYRK2, ENPP1, GOLGA7, HRAS, HTT, IFNG, IL13, LPHN2, LRBA, LY6E, Pdgf, PLOD1, RAB12, RAB33A, SLC1A3, SRM, SV2A, TCF12, TGFB1, UNC5B, ZDHHC9 | 23 | 15 |
| 8 | Developmental Disorder, Neurological Disease, Cell Death | ADAM10, AHCYL2, BCL2L14, CABC1, CORO2A, DUT (includes EG:1854), ERH, F11R, GRPR, LETMD1, MAPK1, MARCKS (includes EG:4082), MEST, NFATC2IP, NMB, NMBR, NMT1, NR3C1, PARK7, PLK3, PMM1, PRKRA, PRPSAP1, REEP5, RNF144B, SH3D19, SLC45A2, SMN1, SNUPN, SPOP, TP53, TRAF6, UBE2T, ZNF259, ZNF346 | 22 | 15 |
| 9 | Cellular Development, Cell Cycle, Connective Tissue Development and Function | ABCD3, ACTC1, Actin, ATP13A5, ATP5J2, ATPase, CDKN2A, CLPX, DDX19B, DONSON, FAM167A, GPHN, HIP1R, HLTF, KATNA1, MED27, MIR373, MIR297-2, NCALD, NSF, ORC5L, PACRGL, PHACTR1, phosphatidylinositol 3,4-diphosphate, PLS1, POLR2H, RNA polymerase II, RSPO1, SDCCAG3 (includes EG:10807), SNX16, SUOX, TBX3, TERT, TOB2, VIM | 21 | 14 |
| 10 | Post-Translational Modification, Cell Cycle, Gene Expression | ACAA1B, CPT2, CUEDC2, DAP, EHHADH, ERBB2, ESR1, FRRS1, GALNT1, GALNT2, GALNT3, GALNT6, HCG 2023776, IGFBP6, LAMP1, LAMP2, MMS19, MRC1, MYC, NCOA4, OLFML3, PAICS, PHF5A, Polypeptide N-acetylgalactosaminyltransferase, PPARG, PTRF, QKI, RAB34, SCG5, SETDB1, SFRP1, STIM1, TPD52, WWC1 | 19 | 13 |
| 11 | Cancer, Cardiovascular Disease, Cell-To-Cell Signalling and Interaction | ALX1, APEH, C20ORF160, COPB2, COX2, COX4I1, DAG1, EPO, FOS, GMFB, GRB2, GRP, GSTK1, GYLTL1B, HCLS1, HNRNPH2, HNRNPR, Hydrolase, KHSRP, MST1R, ONECUT1, P2RY1, PDE6C, PDE6G, POP7, RAB3GAP1, RCC2, RNF128, RPL7, RPS7, RPS18, SMARCD2, TMEM62, USP8, YPEL5 | 19 | 13 |
| 12 | Embryonic Development, Tissue Development, Tissue Morphology | ACOT13, APBB1, BACE1, C11ORF52, CBS, CELA1, Coup-Tf, DCK, DKK1, DSC2, FOXA1, HMGB2, HNF4A, IER5L, JKAMP, KRR1, LRP, LRP2, LRP5, LRP6, MESDC2, NR2F1, NR2F2, PARP4, PHB (includes EG:5245), PKP2, Plasminogen Activator, POU5F1, RSPRY1, Secretase gamma, SLC17A5, TXNDC12, UBE2D3 (includes EG:7323), UBE2V1, WNT4 | 19 | 13 |