Table 3.

HRs and 95% CIs of endometrial cancer related to total, filtered and boiled coffee among 97 926 postmenopausal NOWAC Study participants

No of cups	Total coffee a	Boiled coffee		Filtered coffee
		Combined with other types b	Only boiled coffee	Combined with other types	Only filtered coffee
Age-adjusted HR, CI 95%c
≤ 1 cups/day	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)
2-3 cups/day	0.87 (0.67-1.13)	1.12 (0.83-1.53)	1.03 (0.70-1.51)	0.98 (0.79-1.23)	0.93 (0.70-1.23)
4-7 cups/day	0.76 (0.59-0.99)	1.06 (0.78-1.44)	0.87 (0.59-1.26)	0.89 (0.71-1.13)	0.79 (0.60-1.06)
≥ 8 cups/day	0.44 (0.29-0.67)	0.43 (0.2-0.91)	0.42 (0.19-0.91)	0.48 (0.29-0.79)	0.45 (0.26-0.75)
p for trend	< 0.0001	0.21	0.02	0.002	0.03
Multivariate-adjusted HR, CI 95%d
≤ 1 cups/day	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)
2-3 cups/day	0.91 (0.70-1.19)	1.08 (0.79-1.46)	1.04 (0.71-1.54)	0.99 (0.79-1.24)	0.99 (0.75-1.31)
4-7 cups/day	0.84 (0.65-1.1)	1.10 (0.81-1.50)	0.92 (0.62-1.36)	0.95(0.76-1.20)	0.91 (0.68-1.21)
≥ 8 cups/day	0.52 (0.34-0.79)	0.48 (0.23-1.03)	0.45 (0.21-1.01)	0.55 (0.33-0.91)	0.55 (0.32-0.94)
p for trend	0.003	0.36	0.07	0.12	0.07

^aTotal coffee is combination of responses on total coffee consumption in the total coffee version of the questionnaire and filtered, boiled and instant coffee consumption in the brewing methods version of the questionnaire. ^bCombined with other types: those women who positively responded to question about “total coffee consumption” or/and other brewing method (filtered, boiled, instant). ^cBasic model that was adjusted for age. ^dMultivariate model that was adjusted for parity, smoking status, BMI, duration of OC and HRT use. Abbreviations: HR Hazard ratio, CI Confidence interval, NOWAC Norwegian Women and Cancer, BMI Body mass index, OC Oral contraceptives, HRT Hormone replacement therapy.