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. 2014 Mar 26;14:110. doi: 10.1186/1472-6882-14-110

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Copyright © 2014 Lu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of treatments on the renal histology. (A) Representative photomicrographs of H&E-stained kidney sections from STZ-diabetic rats treated for eight weeks with ruscogenin (RUS) or rosiglitazone (Rosi). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 3 mg/kg RUS (STZ + RUS) or 5 mg/kg RGZ (STZ + Rosi). Normal (normal + Veh) or STZ-diabetic rats receiving vehicle treatment (STZ + Veh) were administered the same volume of vehicle (Veh) used to prepare test medications. Magnification bars = 100 μm (B) Results of quantification of the mesangial expansion index for each group. Values (mean ± SD) were obtained for each group of 5 animals. ^bP < 0.01 compared to vehicle-treated normal rats (normal + Veh). ^cP < 0.05 and ^dP < 0.01 compared to vehicle-treated STZ-diabetic rats (STZ + Veh), respectively.