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. 2014 Mar 26;14:110. doi: 10.1186/1472-6882-14-110

Table 1.

Body and kidney weights, index of renal hypertrophy, and the renal function-related parameters in experimental animals at the end of the eight-week treatment

 
 Normal rats
  
 STZ-diabetic rats
  Vehicle Vehicle Ruscogenin (mg/kg/day)
 Rosiglitazone (5 mg/kg/day)
0.3 1.0 3.0
Body weight (BW) (g/rat)
 374.88 ± 17.92d
 214.84 ± 14.95b
 237.3 ± 17.21b
 261.98 ± 18.32b,c
 291.64 ± 16.24b,c
 315.18 ± 18.10a,d
Plasma glucose (mg/dl)
 92.78 ± 7.32d
 423.12 ± 16.22b
 418.27 ± 15.34b
 412.37 ± 17.41b
 409.87 ± 14.68b
 262.31 ± 13.71b,c
HbAlc (%)
 4.79 ± 1.03d
 14.32 ± 1.79b
 14.10 ± 1.63b
 13.92 ± 1.84b
 13.85 ± 1.65b
 9.63 ± 1.59b,c
Kidney weight (KW) (g/rat)
 1.38 ± 0.17d
 2.28 ± 0.15b
 2.07 ± 0.13b
 1.93 ± 0.21b
 1.85 ± 0.19a,c
 1.79 ± 0.18a,d
KW/BW ratio (%)
 0.37 ± 0.07d
 1.06 ± 0.08b
 0.87 ± 0.09b
 0.74 ± 0.06b,c
 0.62 ± 0.04a,d
 0.57 ± 0.05a,d
24-h urine volume (ml/day)
 8.96 ± 1.76d
 27.30 ± 2.95b
 21.84 ± 3.11b
 19.65 ± 2.43b,c
 17.65 ± 3.05a,c
 15.34 ± 2.62a,c
24-h urine protein (mg/day)
 6.60 ± 2.57d
 28.36 ± 3.95b
 24.11 ± 3.25b
 19.85 ± 2.57,c
 14.82 ± 3.29 a,d
 10.26 ± 4.12a,d
Scr (μmol/l)
 34.07 ± 5.26d
 87.23 ± 7.96b
 70.33 ± 5.83b,c
 69.78 ± 4.92b,c
 62.21 ± 5.61b,c
 56.49 ± 6.92b,c
BUN (mmol/l)
 6.51 ± 0.82d
 18.85 ± 1.13b
 15.68 ± 1.25b,c
 14.27 ± 1.38b,c
 12.66 ± 0.94b,c
 9.71 ± 1.02a,c
Ccr (ml/min) 4.83 ± 0.63d 1.78 ± 0.71b 2.14 ± 0.56b 2.92 ± 0.61b 3.43 ± 0.59a,c 3.71 ± 0.74d

STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with ruscogenin at the indicated dosage, or rosiglitazone. Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to prepare test medications. Values (mean ± SD) were obtained for each group of 8 animals. aP < 0.05 and bP < 0.01 compared to the values of vehicle-treated normal rats, respectively. cP < 0.05 and dP < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.