Table 2.

Univariate and multivariate regression analyses.

		Univariate analysis			Multivariate analysis
	No. of patients (%)	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Time to CRPC	84 (100)
HIF1α inhibitor		0.37	(0.18–0.76)	0.007	0.29	(0.10–0.78)	0.016
Gleason score		1.35	(1.04–1.74)	0.024	1.31	(0.99–1.72)	0.057
Age		0.96	(0.93–1.00)	0.014	1.00	(0.98–1.04)	0.553
PSA		1.00	(1.00–1.00)	0.370	1.00	(1.00–1.00)	0.403
Time to metastases	46 (54)
HIF1α inhibitor		0.29	(0.11–0.77)	0.013	0.19	(0.05–0.76)	0.019
Gleason score		1.44	(1.03–2.01)	0.035	1.50	(1.05–2.13)	0.025
Age		0.97	(0.93–1.01)	0.220	1.00	(0.96–1.06)	0.866
PSA		1.00	(1.00–1.00)	0.947	1.00	(1.00–1.00)	0.284

CRPC, castrate-resistant prostate cancer; HIF, hypoxia-inducible factor; PSA, prostate-specific antigen. Cox proportional univariate analyses of time to castrate resistance and time to metastases are presented. Multivariate regression analyses adjusting for each of the other factors are also presented. Fourteen men (14.3%) were excluded from the analysis as they had missing data.