Table 4.
Biomarkers on tissue collected at baseline, after one cycle, and at time of surgery.
| Biomarker | Baseline (fold expression) | Cycle 1 (fold expression) | Surgery (fold expression) |
|---|---|---|---|
| Thymidine phosphorylase (TYMP) | |||
| N | 21 | 17 | 13 |
| Median (range) | 0.58 (0.11–1.68) | 1.36 (0.41–10.79) | 0.39 (0.09–1.66) |
| Thymidylate synthase (TYMS) | |||
| N | 21 | 17 | 13 |
| Median (range) | 0.22 (0.07–0.63) | 0.32 (0.07–1.1) | 0.16 (0.08–0.77) |
| Dihydropyrimidine dehydrogenase (DPYD) | |||
| N | 21 | 16 | 13 |
| Median (range) | 0.42 (0.11–1.76) | 0.67 (0.24–1.94) | 0.30 (0.15–1.19) |