Table 3.
Genes belonging to the Metabolism of xenobiotic by Cyp450 pathway, identified in DEG lists 1–3.
| Gene Symbol | Entrez gene name | DEG list 1 SNC vs. NS (logFC)1 | DEG list 2 SC vs. NS (logFC)1 | DEG list 3 SC vs. SNC (logFC)1 |
|---|---|---|---|---|
| ADH1A | Alcohol dehydrogenase 1A (class I), α polypeptide | −0.477 | −0.347 | |
| ADH1C | Alcohol dehydrogenase 1C (class I), γ polypeptide | −1.148 | −0.975 | |
| ADH7 | Alcohol dehydrogenase 7 (class IV), μ or σ polypeptide | 1.474 | −1.151 | |
| AKR1B10 | Aldo-keto reductase family 1, member B10 | 4.365 | 2.491 | −1.874 |
| AKR1C1/AKR1C2 | Aldo-keto reductase family 1, member C2 | 1.707 | 0.857 | −0.943 |
| AKR1C3 | Aldo-keto reductase family 1, member C3 | 1.917 | 0.949 | −0.968 |
| AKR1C4 | Aldo-keto reductase family 1, member C4 | 0.624 | −0.338 | |
| ALDH3A1 | Aldehyde dehydrogenase 3 family, member A1 | 2.712 | −1.731 | |
| CSGALNACT1 | Chondroitin sulfate N-acetylgalactosaminyltransferase 1 | −1.035 | −0.763 | |
| CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 3.957 | ||
| CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 2.820 | 1.928 | |
| CYP2A6 | Cytochrome P450, family 2, subfamily A, polypeptide 6 | −0.715 | −0.620 | |
| CYP2B6 | Cytochrome P450, family 2, subfamily B, polypeptide 6 | −0.701 | ||
| CYP2C18 | Cytochrome P450, family 2, subfamily C, polypeptide 18 | 1.016 | 0.618 | |
| CYP3A5 | Cytochrome P450, family 3, subfamily A, polypeptide 5 | 1.528 | ||
| CYP4F11 | Cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.879 | ||
| DHRS9 | Dehydrogenase/reductase (SDR family) member 9 | 1.303 | 0.940 | |
| GSTA1 | Glutathione S-transferase α 1 | −0.408 | ||
| GSTA4 | Glutathione S-transferase α 4 | −0.351 | ||
| GSTM1 | Glutathione S-transferase μ 1 | −0.449 | −0.711 | |
| GSTM2 | Glutathione S-transferase μ 2 (muscle) | −0.459 | −0.726 | |
| GSTM3 | Glutathione S-transferase μ 3 (brain) | −0.819 | ||
| GSTM5 | Glutathione S-transferase μ 5 | −0.847 | −1.155 | |
| GSTP1 | Glutathione S-transferase pi 1 | 0.691 | ||
| GSTT1 | Glutathione S-transferase θ 1 | 1.911 | 1.355 | |
| GSTT2/GSTT2B | Glutathione S-transferase θ 2 | −0.845 | ||
| MGST1 | Microsomal glutathione S-transferase 1 | 0.469 | −0.437 | |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.902 | −0.813 | |
| UGT1A9 | UDP glucuronosyltransferase 1 family, polypeptide A9 | 0.667 | 0.573 | |
| UGT2A1 | UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus | −1.400 |
1
Log fold changes are given for all genes satisfying the selection criteria (FDR < 0.01).