Table 1.
Clinical characteristics and expression profile of galectin-7.
| Patient no. | Case | Group | Gender | Age | Primary site | Differentiation | TN | Stage | G7S | G7NL | Prediction score | Pre C/R | Response to therapy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Learning | Group R | F | 61 | Mandibula | Grade 2 | T4N1 | 4A | 29 | 2 | −2.78 | PF + S/R | NC |
| 2 | Learning | Group R | M | 60 | Maxillary sinus | Grade 3 | T3N2c | 4C | 0 | 0 | −1.97 | P/R | NC |
| 3 | Learning | Group R | M | 50 | Floor of mouth | Grade 2 | T3N2b | 4A | 45.5 | 2 | −1.82 | S/R | NC |
| 4 | Learning | Group R | M | 57 | Tongue | Grade 1 | T2N1 | 3 | 48.4 | 2 | −1.65 | S/R | NC |
| 5 | Learning | Group R | M | 79 | Tongue | Grade 2 | T3N1 | 3 | 48.4 | 2 | −1.65 | S/R | NC |
| 6 | Learning | Group R | M | 32 | Tongue | Grade 1 | T2N2b | 4A | 31.5 | 1 | −1.38 | S/R | NC |
| 7 | Learning | Group R | M | 57 | Tongue | Grade 1 | T3N2b | 4A | 57.7 | 2 | −1.10 | PF + S/R | PD |
| 8 | Learning | Group R | M | 68 | Mandibula | Grade 2 | T4N2b | 4A | 44.9 | 1 | −0.61 | PF | NC |
| 9 | Learning | Group R | M | 47 | Tongue | Grade 2 | T2N0 | 2 | 46.6 | 1 | −0.51 | PF | NC |
| 10 | Learning | Group S | M | 72 | Floor of mouth | Grade 2 | T3N2c | 4A | 72.5 | 2 | −0.25 | S/R | PR |
| 11 | Learning | Group S | M | 50 | Tongue | Grade 1 | T2N0 | 2 | 34.6 | 0 | 0.04 | S | PR |
| 12 | Learning | Group S | M | 82 | Tongue | Grade 1 | T2N0 | 2 | 56.8 | 1 | 0.09 | S | PR |
| 13 | Learning | Group S | M | 59 | Tongue | Grade 2 | T3N0 | 3 | 61.6 | 0 | 1.61 | S/R | PR |
| 14 | Learning | Group S | M | 61 | Tongue | Grade 1 | T2N0 | 2 | 66.5 | 0 | 1.90 | S | PR |
| 15 | Learning | Group S | M | 68 | Lower gingiva | Grade 1 | T2N0 | 2 | 66.6 | 0 | 1.90 | S/R | PR |
| 16 | Learning | Group S | M | 76 | Lower gingiva | Grade 1 | T2N2b | 4A | 78.7 | 0 | 2.60 | S | PR |
| 17 | Learning | Group S | M | 29 | Tongue | Grade 2 | T2N0 | 2 | 80.4 | 0 | 2.70 | S/R | PR |
| 18 | Learning | Group S | M | 53 | Lower gingiva | Grade 1 | T2N1 | 3 | 83.3 | 0 | 2.87 | S | PR |
| 19 | Test | Group R | M | 58 | Mandibula | Grade 2 | T4N2b | 4A | 24.1 | 2 | −3.06 | S | NC |
| 20 | Test | Group R | M | 70 | Floor of mouth | Grade 2 | T2N2c | 4A | 4.53 | 1 | −2.95 | R | NC |
| 21 | Test | Group R | M | 57 | Maxillary sinus | Grade 2 | T4N1 | 4B | 11.4 | 1 | −2.55 | P/R | NC |
| 22 | Test | Group R | F | 66 | Maxillary sinus | Grade 2 | T3N2b | 4A | 12.7 | 1 | −2.47 | S/R | NC |
| 23 | Test | Group R | M | 45 | Tongue | Grade 3 | T3N2b | 4A | 34.4 | 2 | −2.46 | PF | NC |
| 24 | Test | Group R | M | 60 | Tongue | Grade 2 | T4N2c | 4A | 35.3 | 2 | −2.41 | S | NC |
| 25 | Test | Group R | F | 81 | Lower gingiva | Grade 3 | T4N0 | 4A | 16.6 | 1 | −2.25 | R | NC |
| 26 | Test | Group R | F | 72 | Buccal mucosa | Grade 1 | T4N2b | 4A | 0 | 0 | −1.97 | R | NC |
| 27 | Test | Group R | M | 67 | Upper gingiva | Grade 3 | T2N1 | 3 | 0.6 | 0 | −1.93 | S | NC |
| 28 | Test | Group R | M | 53 | Soft palate | Grade 3 | T4N1 | 4A | 8.14 | 0 | −1.50 | R | NC |
| 29 | Test | Group R | M | 59 | Buccal mucosa | Grade 2 | T4N2b | 4A | 31.6 | 1 | −1.38 | R | NC |
| 30 | Test | Group R | M | 53 | Mandibula | Grade 1 | T4N2b | 4A | 33.4 | 1 | −1.27 | R | NC |
| 31 | Test | Group R | M | 68 | Mandibula | Grade 2 | T4N2b | 4A | 56.1 | 2 | −1.20 | S | NC |
| 32 | Test | Group R | F | 54 | Tongue | Grade 2 | T2N2b | 4A | 37 | 1 | −1.06 | S | NC |
| 33 | Test | Group R | F | 52 | Lower gingiva | Grade 2 | T4N2c | 4A | 60.8 | 2 | −0.93 | S | NC |
| 34 | Test | Group R | M | 61 | Retromolar trigone | Grade 1 | T4N1 | 4A | 40.7 | 1 | −0.85 | S | NC |
| 35 | Test | Group R | M | 41 | Tongue | Grade 3 | T2N2c | 4A | 20.2 | 0 | −0.79 | R | NC |
| 36 | Test | Group R | M | 66 | Mandibula | Grade 1 | T4N2b | 4A | 43 | 1 | −0.72 | S | NC |
| 37 | Test | Group R | M | 74 | Lower gingiva | Grade 2 | T4N2b | 4A | 68 | 2 | −0.51 | S | NC |
| 38 | Test | Group R | M | 69 | Tongue | Grade 2 | T3N2b | 4A | 25.8 | 0 | −0.47 | PF | NC |
| 39 | Test | Group R | M | 57 | Mandibula | Grade 1 | T4N0 | 4A | 31.8 | 0 | −0.12 | R | NC |
| 40 | Test | Group R | M | 64 | Tongue | Grade 2 | T3N2c | 4A | 75 | 2 | −0.10 | PF | NC |
| 41 | Test | Group R | M | 62 | Maxila | Grade 2 | T4N1 | 4A | 33 | 0 | −0.05 | S/R | NC |
| 42 | Test | Group R | M | 57 | Tongue | Grade 2 | T2N0 | 2 | 33.1 | 0 | −0.04 | S/R | NC |
| 43 | Test | Group R | M | 64 | Tongue | Grade 2 | T3N2b | 4A | 72.4 | 1 | 0.99 | S | NC |
| 44 | Test | Group S | M | 57 | Maxillary sinus | Grade 2 | T3N0 | 3 | 0.7 | 2 | −4.42 | P/R | PR |
| 45 | Test | Group S | M | 52 | Lower gingiva | Grade 2 | T2N2b | 4A | 1.35 | 2 | −4.38 | S/R | PR |
| 46 | Test | Group S | M | 55 | Tongue | Grade 3 | T3N2b | 4A | 6.63 | 1 | −2.83 | PF | PR |
| 47 | Test | Group S | M | 74 | Upper gingiva | Grade 3 | T4N2b | 4A | 9.94 | 1 | −2.64 | S/R | PR |
| 48 | Test | Group S | M | 62 | Tongue | Grade 3 | T3N0 | 3 | 10.9 | 1 | −2.58 | S/R | PR |
| 49 | Test | Group S | M | 71 | Buccal mucosa | Grade 3 | T3N2b | 4B | 39.9 | 2 | −2.14 | PF | PR |
| 50 | Test | Group S | F | 76 | Upper gingiva | Grade 2 | T4N0 | 4A | 0 | 0 | −1.97 | S/R | PR |
| 51 | Test | Group S | F | 52 | Tongue | Grade 3 | T3N0 | 3 | 2.1 | 0 | −1.85 | S/R | PR |
| 52 | Test | Group S | M | 50 | Tongue | Grade 1 | T2N0 | 2 | 6.2 | 0 | −1.61 | S/R | PR |
| 53 | Test | Group S | M | 49 | Tongue | Grade 2 | T3N1 | 3 | 27.9 | 1 | −1.60 | PF | PR |
| 54 | Test | Group S | M | 48 | Lower gingiva | Grade 1 | T4N0 | 4A | 31.1 | 1 | −1.41 | S/R | PR |
| 55 | Test | Group S | M | 62 | Lower gingiva | Grade 2 | T3N2b | 4A | 33.1 | 1 | −1.29 | S/R | PR |
| 56 | Test | Group S | M | 58 | Floor of mouth | Grade 2 | T2N2c | 4A | 11.9 | 0 | −1.28 | R | PR |
| 57 | Test | Group S | M | 61 | Upper gingiva | Grade 3 | T4N0 | 4A | 12.2 | 0 | −1.26 | P/R | PR |
| 58 | Test | Group S | M | 59 | Floor of mouth | Grade 2 | T4N2c | 4A | 33.7 | 1 | −1.26 | PF | PR |
| 59 | Test | Group S | F | 67 | Tongue | Grade 2 | T2N2c | 4A | 34.8 | 1 | −1.19 | PF | PR |
| 60 | Test | Group S | F | 64 | Upper gingiva | Grade 2 | T3N0 | 3 | 37.1 | 1 | −1.06 | S/R | PR |
| 61 | Test | Group S | M | 58 | Lower gingiva | Grade 2 | T3N1 | 3 | 59 | 2 | −1.03 | S/R | PR |
| 62 | Test | Group S | M | 54 | Lower gingiva | Grade 2 | T2N2b | 4A | 16.7 | 0 | −1.00 | S/R | PR |
| 63 | Test | Group S | M | 69 | Tongue | Grade 2 | T3N0 | 3 | 20.8 | 0 | −0.76 | S/R | PR |
| 64 | Test | Group S | M | 65 | Tongue | Grade 1 | T3N0 | 3 | 26.5 | 0 | −0.43 | PF | PR |
| 65 | Test | Group S | F | 40 | Tongue | Grade 2 | T2N2b | 4A | 27.9 | 0 | −0.35 | S/R | PR |
| 66 | Test | Group S | M | 54 | Lower gingiva | Grade 2 | T4N0 | 4A | 28.3 | 0 | −0.32 | R | PR |
| 67 | Test | Group S | M | 55 | Tongue | Grade 1 | T3N1 | 3 | 30.9 | 0 | −0.18 | S/R | PR |
| 68 | Test | Group S | M | 59 | Floor of mouth | Grade 2 | T2N0 | 2 | 52.3 | 1 | −0.17 | S/R | PR |
| 69 | Test | Group S | M | 67 | Floor of mouth | Grade 2 | T4N1 | 4A | 31.1 | 0 | −0.16 | S/R | PR |
| 70 | Test | Group S | F | 64 | Lower gingiva | Grade 1 | T4N1 | 4A | 35.6 | 0 | 0.10 | S/R | PR |
| 71 | Test | Group S | M | 65 | Tongue | Grade 1 | T3N1 | 3 | 80 | 2 | 0.19 | PF | PR |
| 72 | Test | Group S | M | 66 | Floor of mouth | Grade 2 | T3N0 | 3 | 60.7 | 1 | 0.31 | PF | PR |
| 73 | Test | Group S | M | 65 | Retromolar trigone | Grade 2 | T2N0 | 2 | 41.4 | 0 | 0.44 | R | PR |
| 74 | Test | Group S | M | 75 | Upper gingiva | Grade 3 | T4N2c | 4A | 41.4 | 0 | 0.44 | S/R | PR |
| 75 | Test | Group S | F | 62 | Maxila | Grade 1 | T4N0 | 4A | 42.6 | 0 | 0.51 | PF/R | PR |
| 76 | Test | Group S | F | 52 | Tongue | Grade 2 | T2N0 | 2 | 43.1 | 0 | 0.53 | S/R | PR |
| 77 | Test | Group S | M | 59 | Tongue | Grade 1 | T3N2c | 4A | 47 | 0 | 0.76 | R | PR |
| 78 | Test | Group S | M | 48 | Tongue | Grade 2 | T3N2b | 4A | 51.5 | 0 | 1.03 | PF | PR |
| 79 | Test | Group S | M | 62 | Buccal mucosa | Grade 2 | T2N0 | 2 | 52.8 | 0 | 1.10 | S/R | PR |
| 80 | Test | Group S | F | 46 | Tongue | Grade 2 | T3N0 | 3 | 54.3 | 0 | 1.18 | S/R | PR |
| 81 | Test | Group S | M | 45 | Lower gingiva | Grade 1 | T4N1 | 4A | 54.4 | 0 | 1.19 | S/R | PR |
| 82 | Test | Group S | M | 45 | Floor of mouth | Grade 1 | T2N0 | 2 | 55.2 | 0 | 1.24 | S/R | CR |
| 83 | Test | Group S | M | 56 | Tongue | Grade 3 | T3N0 | 3 | 55.9 | 0 | 1.28 | S/R | PR |
| 84 | Test | Group S | F | 62 | Lower Gingiva | Grade 2 | T3N0 | 3 | 60.2 | 0 | 1.53 | R | PR |
| 85 | Test | Group S | M | 58 | Soft palate | Grade 2 | T3N0 | 3 | 69.9 | 0 | 2.09 | S/R | PR |
| 86 | Test | Group S | M | 68 | Lower gingiva | Grade 1 | T4N0 | 4A | 71.6 | 0 | 2.19 | S/R | PR |
Group R, resistant group; Group S, sensitive group; M, male; F, female; Pre C/R, preoperative chemotherapy and/or radiotherapy; S/R, S-1 + radiation; P/R, carboplatin or cisplatin + radiation; PF/R, cisplatin and 5-fluorouracil + radiation; PF, cisplatin and 5-fluorouracil; S, S-1; R, radiation; CR, complete remission; PR, partial response; SD, stable disease; PD, progressive disease.