Table 1.
Baseline characteristics of the cases and their matched controls.
| Characteristic | Cases (n = 562) | Controls (n = 993) | P-value |
|---|---|---|---|
| Age, mean (range) | 62 (18–92) | 62 (30–87) | 0.71 |
| Sex, n (%) | |||
| Male | 352 (63) | 624 (63) | 0.97 |
| Female | 210 (37) | 369 (37) | |
| Smoking status, n (%) | |||
| Current smokers | 129 (23) | 226 (23) | 0.65 |
| Ex-smokers | 240 (43) | 424 (43) | |
| Never-smokers | 193 (34) | 343 (35)1 | |
| Pack-year history, mean (range) | 44 (0.1–218) | 29 (2–190) | <0.0005 |
| Family history of UADT cancers, n (%) | |||
| Yes | 23 (4) | 39 (4) | 0.60 |
| No | 539 (96) | 954 (96) | |
| Cancer type, n (%) | |||
| Lung | 268 (48) | ||
| Esophageal | 110 (20) | ||
| Head and neck | 184 (33)1 | ||
| Histology, n (%) | |||
| Adenocarcinoma | 233 (41) | ||
| Squamous cell carcinoma | 309 (55) | ||
| Large cell carcinoma | 20 (4) | ||
| Stage, n (%) | |||
| I | 435 (77) | ||
| II | 127 (23) | ||
| ECOG performance status, n (%) | |||
| 0–1 | 469 (83) | ||
| 2 or greater | 93 (17) | ||
UADT, upper aerodigestive tract.
1
Percentages do not add up to 100% due to rounding.