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TEM observation of TiO2-NP accumulation, in vitro. TiO2-NP distribution in a Caco-2 monoculture (A-C), a Caco-2/HT29-MTX co-culture (D-F), and a Caco-2/RajiB co-culture (G-L) exposed on their apical pole to 50 μg/mL of TiO2-NPs for 48 h. tw.: transwell insert on which cells are grown, making possible the identification of the basolateral pole (bl.), on the opposite side of the apical pole (ap.). Ti-rich zones are pointed out with arrows.
