Table 2.
Dose-Dependent Effects of PCB153 on Terminal Body, Body Weight Gain, Absolute Liver Weight and Relative Liver Weight at 24 h.
| Dose (mg/kg) | Treatment | Terminal body weight (g) |
Body weight gain | Liver weight (g) | Relative liver weight |
|---|---|---|---|---|---|
| 0 | Vehicle | 11.8 ± 1.9 | 1.1 ± 0.0 | 0.694 ± 0.085 | 0.059 ± 0.006 |
| 1 | PCB153 | 14.3 ± 1.8 | 1.1 ± 0.0 | 0.850 ± 0.121 | 0.059 ± 0.002 |
| 3 | PCB153 | 14.4 ± 1.7 | 1.1 ± 0.0 | 0.865 ± 0.119 | 0.060 ± 0.002 |
| 10 | PCB153 | 12.7 ± 1.1 | 1.1 ± 0.1 | 0.721 ± 0.073 | 0.056 ± 0.004 |
| 30 | PCB153 | 13.4 ± 1.0 | 1.1 ± 0.0 | 0.836 ± 0.066 | 0.062 ± 0.001 |
| 100 | PCB153 | 13.8 ± 1.1 | 1.1 ± 0.0 | 0.829 ± 0.071 | 0.060 ± 0.002 |
| 300 | PCB153 | 12.7 ± 1.9 | 1.1 ± 0.0 | 0.855 ± 0.152 | 0.067 ± 0.003* |
Values represent mean ± SD of five independent replicates. Body weight gain is represented as terminal body weight divided by body weight prior to dosing.
Asterisk indicates p<0.05 (PCB153 vs. vehicle).