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. 2014 Apr 14;205(1):67–81. doi: 10.1083/jcb.201401045

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© 2014 Jones et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Assembly of the AIS coat during neuron maturation. (A–F) Representative PREM images of proximal axons showing their typical structural features at indicated DIV. (A and B) Loosely aligned (A) or bundled (B) MTs. (C) Loose fibrillar (arrows) coat containing sparse globules (inset). (D) Dense fibrillar–globular coat. (E) Dense mostly globular coat with some fibrils. (F) Mature mostly globular coat with some thin parallel fibrils (inset). Bar, 200 nm. (G) Categorization of proximal axons based on prevalent structural features within the middle 50% of AIS length, where coat density is most uniform (top, diagram). Graph shows the percentage of neurons in each category at different time points. DIV3/4, n = 38; DIV7, n = 31; DIV10, n = 14; DIV14, n = 11; DIV21, n = 12.