Table 3.
Percentage who progressed to incident CKD*, according to different definitions of RP
| Years of follow-up considered | Number of eGFR per year | Excluded in analysis |
RP definition A |
RP definition B |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
a
RP (PPV) |
b
non-RP (1-NPV) |
Sensitivity (%) |
Specificity (%) |
RP (PPV) |
non-RP (1-NPV) |
Sensitivity (%) |
Specificity (%) |
|||
| Declines of >5 ml/min/1.73 m 2 required to meet the RP definition | ||||||||||
| Four |
Three |
65/18948 (0.3) |
13/108(12.0) |
21/3547 (0.6) |
38.2 |
97.4 |
0/15 (0.0) |
34/3640 (0.9) |
0.0 |
99.6 |
| Four |
Two |
42/14305 (0.3) |
23/256 (9.0) |
34/8042 (0.4) |
40.4 |
97.2 |
2/43 (4.7) |
55/8255 (0.7) |
3.5 |
99.5 |
| Three |
Three |
47/16228 (0.3) |
15/195 (7.7) |
37/6180 (0.6) |
28.8 |
97.2 |
4/85 (4.7) |
48/6290 (0.8) |
7.7 |
98.7 |
| Three |
Two |
24/10320 (0.2) |
20/369 (5.4) |
55/11914 (0.5) |
26.7 |
97.1 |
7/173 (4.1) |
68/12110 (0.6) |
9.3 |
98.6 |
| Two |
Three |
28/11847 (0.2) |
14/355 (3.9) |
57/10401 (0.6) |
19.7 |
96.8 |
16/476 (3.4) |
55/10280 (0.5) |
22.5 |
95.7 |
| Two |
Two |
7/5392 (0.1) |
20/602 (3.3) |
72/16609 (0.4) |
21.7 |
96.6 |
23/779 (3.0) |
69/16432 (0.4) |
25.0 |
95.6 |
| |
|
|
Declines of >3 ml/min/1.73 m
2
required to meet the RP definition |
|||||||
| Four |
Three |
65/18948 (0.3) |
18/218 (8.3) |
16/3437 (0.5) |
52.9 |
94.5 |
3/37 (8.1) |
31/3618 (0.9) |
8.8 |
99.1 |
| Four |
Two |
42/14305 (0.3) |
27/506 (5.3) |
30/7792 (0.4) |
47.4 |
94.2 |
6/97 (6.2) |
51/8201 (0.6) |
10.5 |
98.9 |
| Three |
Three |
47/16228 (0.3) |
21/325 (6.5) |
31/6050 (0.5) |
40.4 |
95.2 |
8/151 (0.7) |
44/6224 (27.5) |
15.4 |
97.7 |
| Three |
Two |
24/10320 (0.2) |
25/602 (4.2) |
50/11681 (0.4) |
33.3 |
95.3 |
14/292 (4.8) |
61/11991 (0.5) |
18.7 |
97.7 |
| Two |
Three |
28/11847 (0.2) |
20/527 (3.8) |
51/10229 (0.5) |
28.2 |
95.3 |
22/633 (2.8) |
49/10123 (0.5) |
31.0 |
94.3 |
| Two | Two | 7/5392 (0.1) | 30/885 (3.4) | 62/16326 (0.4) | 32.6 | 95.0 | 32/1021(4.5) | 60/16190 (0.4) | 34.8 | 94.2 |
*Two consecutive eGFR measurements <60 ml/min/1.73 m2.
aRP: Rapid Progressors who developed CKD (i.e., the positive predictive value (PPV)).
bNon-RP: non-Rapid Progressors who developed CKD (i.e., 1-negative predictive value (NPV)).