Table 1.

Definitions

Measure	Definition	Population	Analysis
Parasite clearance	Patients’ conversion from a positive to a negative parasite slide within 7 days post-treatment start (independent of whether it was sustained throughout the entire duration of follow-up or there was a recurrent episode).	All studies, whether comparative or not (n = 15,017)	Observed median time of parasite clearance
Delayed parasite clearance	- Parasitaemia positive on		Prevalence, risks by multivariate analysis
	o Day 2
	o Day 3
Parasite clearance failure	- Day 2 parasitaemia > pre-treatment parasitaemia
	- Day 3 parasitaemia >25% pre-treatment parasitaemia
	- Consecutive positive slides up to Day 7
Parasite reduction ratio	Relative difference (referent: parasite before treatment)	ASAQ groups (n = 2,355) where parasite densities were measured once daily from Days 0 to 3 and Day 7	Reduction rate
Predicted time of parasite clearance	Modelling the time of parasite clearance		Predict the time of parasite clearance using the parasitaemia before treatment and the proportions of positive patients