Table 1.
Studies regarding surgical approach for older patients diagnosed with early stage colorectal cancer.
| Author/study | Type of study | No. of patients | No. of older patients (%)/ age cutoff (years) |
Endpoints | Outcome |
|---|---|---|---|---|---|
|
Damhuis et al. [1996] |
Data analysis, retrospective |
6457 | 1549 (24%)/ 80 |
(i) Resection rate (ii) 30-day postoperative mortality |
(i) 82.1% for 80–89 years, 67.2% for >90 years (ii) 1.2% for <60 years, 9.8 % for >80 years |
|
Rutten et al. [2008] |
Data analysis (a) Dutch TME study (b) Dutch Comprehensive Cancer Centres |
5923 |
1508 (25.4%)/ 75 |
Older versus younger patients: (i) 1 month (ii) 6-month postoperative (TME) mortality |
(a) (i) 6.5% in patients aged 75–84 years versus 3.2% in patients aged 65–74 years ( ii) 13.4% versus 4.6% (b) (i) 3.7% versus 1.1% (ii) 13.4% versus 4.9% |
|
Aparicio et al. [2009] |
Database analysis, retrospective |
110 |
110 (100%)/ 75 |
Management analysis |
52% received substandard treatment: 87% received surgical treatment 26% adjuvant CT 16% palliative CT |
|
Fontani et al. [2011] |
Observational analysis, prospective |
914 |
352 (38.5%)/ 75 |
Older versus younger patients: (i) perioperative mortality (ii) 3-year, 5-year, 10-year OS |
(i) 5.9% versus 2.1% (p = 0.003) (ii) 3-year OS: 37% versus. 52.3% 5-year OS: 16.2% versus 35.1% 10-year OS: 5.1 versus 24.7% (p < 0.005) |
|
Maas et al. [2013] |
Data analysis, retrospective |
642 (a) n = 346 (b) n = 296 |
642 (100%)/ 75 |
Preoperative RT + surgery (a) Versus surgery alone (b): (i) local recurrence (ii) postoperative complications |
(i) 2% versus 6% (p = 0.002) (ii) 58% versus 42% (p < 0.0001) |
CT, chemotherapy; OS, overall survival; RT, radiation therapy; TME, total mesorectal excision.