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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Leuk Lymphoma. 2013 Jul 25;55(4):884–891. doi: 10.3109/10428194.2013.815351

Figure 2.

Figure 2

RUNX1–ETO- and RUNX1–ETO9a-induced IFN response requires IFNAR. (A) RE and RE9a expression in wild-type and Ifnar1−/− in total murine bone marrow cells. Following retroviral transduction and selection, bone marrow cells were analyzed by Western blot to confirm RE and RE9a expression. α-Tubulin serves as a loading control. (B) Expression of Ifn-α and Ifn-β in transduced bone marrow cells. Expression levels were normalized to Gapdh with control-transduced cells of each genotype set to 1. Data show averages and standard deviations of three independent experiments. (C) Expression of IFN-stimulated genes in transduced bone marrow cells. Expression levels were normalized to Gapdh and respective wild-type or Ifnar1−/− control-transduced cells. Data show averages and standard deviations of three independent experiments.