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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Leukemia. 2013 Jul 1;27(12):2272–2279. doi: 10.1038/leu.2013.197

Figure 1. Inhibition of JAK1 and JAK2 attenuates the colony-forming ability of AML1-ETO- and AE9a-transformed cells.

Figure 1

CFU assays of AML1-ETO- and AE9a-transformed mouse fetal liver or bone marrow cells after control, JAK1 or JAK2 shRNA expression (A). CFU assays of AML1-ETO (B) and AE9a (C) transformed mouse bone marrow cells in the presence of TG101209 or INCB18424 at the concentrations indicated. Colony numbers are presented as percentages of control shRNA (A) or DMSO controls (B) and (C). Averages with SEM of at least two independent experiments are shown. Statistical significance of each treatment compared with the control is indicated above each bar. Statistical significance between two different treatments is also indicated. The cells treated with 600 nM (C) and 1200 nM (B and C) TG101209 failed to generate any colonies and therefore a p-value cannot be calculated. ** p < 0.01, ‡ p < 0.001, # p < 0.0001