Table 3.
Cognitive test scores and composite domain scores at follow-up compared to baseline
| Test variables | Raw scores |
Z-scores and statistics |
|||
|---|---|---|---|---|---|
| IIH baseline | IIH follow-up | ||||
| n=31 | n=29 | Z* | 95% CI | p Value | |
| Executive function | −0.18 | −0.77 to 0.42 | 0.16 | ||
| Intra–extra dimensional set shift | |||||
| ID/ED Errorslog | 8.1 (0–32) | 5.8 (1–32) | −0.82 | −1.40 to −0.25 | 0.77 |
| Total errors adjustedlog | 20.9 (7–177) | 14.4 (7–68) | −0.56 | −1.14 to 0.01 | 0.26 |
| Stockings of Cambridge | |||||
| Solved in minimum moves | 9.61 (2) | 19.9 (2) | −0.08 | −0.66 to 0.49 | 0.55 |
| Initial thinking timelog, s | 6.5 (2–18.3) | 6.7 (2.5–18.4) | 0.45 | −0.14 to 1.02 | 0.98 |
| Subsequent thinking timelog, s | 0.013 (0–3.7) | 0.013 (0–3.7) | 0.11 | −0.47 to 0.68 | 0.85 |
| Trail Making Test† | |||||
| Trail Making B-Alog, s | 39.2 (14.7–101.1) | 33.1 (1.3–79.5) | 0.46 | −0.12 to 1.05 | 0.002 |
| Working memory | −0.33 | −0.84 to 0.18 | 0.44 | ||
| Spatial working memory | |||||
| Strategy scorelog | 29.9 (20–42) | 27.9 (19–42) | −0.24 | −0.81 to 0.34 | 0.1 |
| Total errorslog | 10.2 (0–79) | 10.1 (0–61) | −0.24 | −0.81 to 0.34 | 0.5 |
| Spatial span | |||||
| Span length | 6.4 (1.3) | 6.4 (1.3) | −0.27 | −0.85 to 0.31 | 0.96 |
| Processing speed | −1.23 | −1.83 to −0.64 | 0.49 | ||
| Verbal Fluency† | |||||
| Letters | 19.4 (7.0) | 18.6 (6.6) | −1.27 | −1.86 to −0.69 | 0.88 |
| Categories | 39.8 (9.9) | 42.5 (10.8) | −0.93 | −1.51 to −0.34 | 0.41 |
| Trail Making Test† | |||||
| Trail Making Alog, s | 31.5 (18.0–68.1) | 32.9 (9.8) | −0.56 | −1.15 to 0.02 | 0.95 |
| Trail Making Blog, s | 73.5 (40.9–169.2) | 66.1 (38.7–125.4) | −0.18 | −0.79 to 0.4 | 0.16 |
| Symbol digit modalities | |||||
| Correct symbols | 47.8 (10.2) | 49.1 (12.3) | −0.91 | −1.49 to −0.33 | 0.5 |
| Visuospatial memory | 0.39 | −0.17 to 1.02 | 0.0005 | ||
| Rey-Osterrieth figure | |||||
| Immediate recall, score | 24.5 (5.4) | 28.9 (4.1) | 0.36 | −0.22 to 0.93 | 0.002 |
| Delayed recall, score | 23.8 (5) | 28.8 (3.8) | 0.31 | −0.26 to 0.89 | 0.0002 |
| Attention | |||||
| Rapid visual processing | |||||
| A’ sensitivity to target | 0.9 (0.1) | 0.92 (0.04) | −0.14 | −0.71 to 0.43 | 0.03 |
| Reaction time | −1.31 | −1.90 to −0.71 | 0.9 | ||
| Reactionlog, ms | 428.7 (264.9–988.6) | 387.4 (393–710.1) | −1.45 | −2.02 to −0.88 | 0.68 |
| Movement, ms | 417.8 (86.3) | 412.3 (72.1) | −0.89 | −1.46 to −0.31 | 0.32 |
Normally distributed raw score variables are shown as mean (SD). Logarithmically transformed variableslog are shown as arithmetic mean (range). Z-scores and test statistics are given in estimates from a linear mixed model adjusting for education and headache at the time of testing and multiple testing. Significant p values are printed in italic.
*Z Patients at follow-up compared to healthy controls.
†n=29, as Trail Making Test scores and Verbal Fluency scores from non-native Danish speakers (n=2) were omitted from analysis.
IIH, intracranial hypertension.