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. 2012 Apr 10;5:23–30. doi: 10.4137/CGast.S7625

Table 4.

Most common adverse reactions.

Adverse reaction Lubiprostone (8 μq twice daily) n = 1011 Placebo
Nausea 8% 4%
Diarrhea 7% 4%
Abdominal pain 5% 5%
Abdominal distention 3% 2%