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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Sci Signal. 2013 Jul 16;6(284):ra58. doi: 10.1126/scisignal.2003994

Fig. 4. A consensus model for the six RTKs reveals a core signaling backbone and RTK class-specific interactions.

Fig. 4

(A) RTK backbone edges (relationships) are shown in thick black lines, whereas class-specific relationships are colored and correspond to (B). Nodes are colored according to their approximate biological function, and tyrosine- and serine/threonine-containing phosphorylation epitopes are shown as ovals and boxes, respectively (noted in insert; Txn, transcription). (B) Venn diagram showing shared and class-specific edges across the three RTK classes. All IGF-1R/NTRK2 edges and all but one of the PDGFRβ edges are present in the EGFR/FGFR1/c-Met network. (C) Median signal values (across all time points, shRNA conditions, and biological replicates) for each phosphosite in each cell line relative to the EGFR cell line.