Table 3.
Necropsy
| Before Iso
|
4d Iso
|
p
|
|||||
|---|---|---|---|---|---|---|---|
| CON (8) | AC6KO (8) | CON (8) | AC6KO (8) | Interaction | AC6 effect | Iso effect | |
| LV (mg) | 92.5±4.8 | 91.0±3.9 | 105.1±6.5 | 102.1±7.2 | ns | ns | <0.05 |
| BW (g) | 25.6±0.7 | 26.7±1.0 | 29.7±1.8 | 28.5±1.5 | ns | ns | <0.04 |
| LV/BW (mg/g) | 3.7±0.1 | 3.6±0.2 | 3.9±0.3 | 3.7±0.3 | ns | ns | ns |
| TL (mm) | 17.5±0.2 | 17.6±0.3 | 17.4±0.2 | 17.6±0.3 | ns | ns | ns |
| LV/TL (mg/mm) | 5.3±0.2 | 5.1±0.2 | 6.6±0.4 | 5.8±0.4 | ns | ns | <0.004 |
| Liver (g) | 1.2±0.1 | 1.2±0.1 | 1.3±0.1 | 1.2±0.2 | ns | ns | ns |
| Lung (mg) | 182.0±5.6 | 188.4±13.4 | 177.0±12.6 | 181.5±10.2 | ns | ns | ns |
LV, left ventricle; BW, body weight; LV/BW, left ventricle/body weight ratio; TL, tibial length; LV/TL, left ventricle weight/tibial length ratio; ns, not significant. Data are mean±SEM. Probability values are from 2-way ANOVA for interaction, AC6 effect (absence of AC6), and Iso (isoproterenol) effect.