Table 1.

The doses assigned on the four design levels using the k-adjustment factor and the dose m _i at level i

Design level I (3 animals)	Design level 2 (5 animals)		Design level 3 (7 animals)		Design level 4 (9 animals)
Outcome	Dose (m 2 )	Outcome	Dose (m 3 )	Outcome	Dose (m 4 )	Outcome
0	m + m/k	0	m2 + m/k2	0	m3 + m/k3	0
1	m + m/k2	1	m2 + m/k3	1	m3 + m/k4	1
2	m - m/k2	2	m2 + m/k4	2	m3 + m/k5	2
3	m - m/k	3	m2 - m/k4	3	m3 + m/k6	3
		4	m2 - m/k3	4	m3 - m/k6	4
		5	m2 - m/k2	5	m3 - m/k5	5
				6	m3 - m/k4	6
				7	m3 - m/k3	7
						8
						9

The dose m = m₁ is the starting dose. The number of mice used on the design levels was 3, 5, 7 and 9, respectively.