Table 4.
Comparisons of optimised 3-level RSP Design, UDPs and Random Walk Design in estimation of LD 50 of YTX
| Design | Dose (μg/kg BW) | Proportion of dead mice | LD 50 with 95% CI (μg/kg BW) |
|---|---|---|---|
| Multinomial outcome variable with 3-level RSP design |
400 |
1/3 |
453 (380 – 513) |
| 475 |
4/7 |
||
| 500 |
3/5 |
||
| UDP of OECD |
225 |
0/1 |
400 (198 – 977) |
| 400 |
0/3 |
||
| 710 |
2/2 |
||
| Simple UDP |
225 |
0/6 |
400 (65.2 – 580) |
| 400 |
3/6 |
||
| 710 |
2/3 |
||
| Random walk design | 225 |
0/6 |
400 (65.2 – 580) |
| 400 |
3/6 |
||
| 710 | 2/3 |
The results are expressed with 95% Confidence Intervals.