Liver expressed antimicrobial peptide-2 (LEAP-2) gene expression in colon tissue. Relative expression of LEAP-2 mRNA was measured using gene array as described in the methods. The levels of LEAP-2 expressions were compared between the enrolled groups using the Student t test. Data was presented using vertical box and whiskers graph. The horizontal lines represent the median values. The vertical lines represent the SDs. The box represents the 75% percentile of the data. LEAP-2 expression is significantly higher (p<0.05) in control groups compared with HIV-monoinfected, HCV-monoinfected and HIV/HCV-coinfected patients (mean±SD: 6.9±0.6, 5.80±0.4, 5.84±0.5, and 5.84±0.5, respectively). The differences between the controls and HIV-monoinfected, HCV-monoinfected and HIV/HCV-coinfected patients were significant (p=0.02, p=0.04, and p=0.03, respectively). No significant difference was observed among patient groups.