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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Ann Allergy Asthma Immunol. 2014 Feb 5;112(4):354–360.e1. doi: 10.1016/j.anai.2014.01.013

Table 2.

Summary of PC20 measurements at each follow-up visit

Randomization After period A After washout After period B
HD then LD ICS (n = 32) on LD ICS (run-in) after HD ICS on LD ICS (washout) after LD ICS
    PC20
        N 32 28 27 26
        Geometric mean (raw PC20 range) 0.90 (0.11–7.13) 1.19 (0.10–26.92) 0.64 (0.008–14.49) 1.25 (0.008–48.00)
        PC20 >32 mg/mLa 0 0 0 1
        Missing 0 4 5 5
LD then HD ICS (n = 30) on LD ICS (run-in) after LD ICS on LD ICS (washout) after HD ICS
    PC20
        N 29 23 23 20
        Geometric mean (raw PC20 range) 1.56 (0.09–7.16) 2.04 (0.16–48.00) 1.39 (0.14–30.55) 4.31 (0.32–48.00)
        PC20 >32 mg/mLa 0 2 0 4
        Missing 1 5 7 6

Abbreviations: HD, high-dose; ICS, inhaled corticosteroid; LD, low-dose; PC20, provocative concentration of methacholine causing a 20% decrease in forced expiration in 1 second.

a

The number of participants who did not achieve PC20 at 32 mg/mL is listed and the multiple imputation was used in the calculation of the geometric mean of PC20 to include data from as many participants as possible in the analysis.