Table 3.
Association between serum protein levels and the gene-expression levels of the macrophage markers.
sCD163 | IL-6 | MCP-1 | |
---|---|---|---|
mRNA | |||
CD14 | 0.33* | 0.23* | 0.50** |
CD68 | 0.38** | 0.30* | 0.34* |
CD163 | 0.37** | 0.34* | 0.43** |
CD206 | 0.38** | 0.28* | 0.47** |
IL-10 | 0.37** | 0.23* | 0.45** |
TNF-α | 0.22* | 0.27* | 0.33* |
IL-6 | 0.17 | 0.25* | 0.44* |
MCP-1 | 0.30* | 0.28* | 0.46** |
Subcutaneous AT and blood samples from obese and lean subjects (n = 92).
Gene-expression levels of the general macrophage markers: CD14 and CD68, the anti-inflammatory markers: CD163, CD206, and IL-10, and the proinflammatory markers: TNF-α, IL-6 and MCP-1 relative to the house-keeping gene LRP10 measured by RT-PCR. Circulating levels of sCD163, IL-6, and MCP-1 measured by ELISA.
Statistic tests: Spearman's correlation test; r: correlations coefficient.
*P < 0.05; **P < 0.001.