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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2008 Nov 11;79(0):131–134. doi: 10.1016/j.plefa.2008.09.002

Fig. 2.

Fig. 2

Membrane proteins sense the pressure profile of a lipid bilayer. Lipids are compressed laterally by the hydrophobic effect (red arrows). When the protein undergoes a conformational change it performs work against membrane lateral pressure which is a contribution to free energy of protein conformers.