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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: J Immunol. 2012 Jan 27;188(5):2093–2101. doi: 10.4049/jimmunol.1101118

Figure 1. Adjuvant-treatment with CFA attenuated clinical EAE, but did not increase apoptosis of CNS-infiltrating T cells.

Figure 1

(A) The experimental design is shown. Adjuvant-EAE mice were treated with CFA on the left flank or mice were left untreated for EAE-only. On day 21 after CFA treatment, EAE was induced in mice with (MOG35–55) emulsified in CFA. (B) Clinical course of EAE in naïve and adjuvant-treated WT mice. (*P=0.02 Mann-Whitney Test) (C) The percentage of apoptotic CNS-infiltrating CD4+ T cells was measured by Annexin-V/PI staining at the end of the experiment (day 21). Shown is the mean and SD of 4 mice per group (**P≤0.002 by T-test); two independent experiments were done.