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Cisplatin-induced DNA damage is increased with MK-1775 treatment. (A) Immunofluorescence images of Daoy cells treated with an IC30 of MK-1775 or an IC25 of cisplatin or both drugs for the time periods as indicated. Cells were stained with DAPI (blue) for total DNA content and with an antibody against γH2AX (green) to visualize DNA damage. (B) Quantifying bar graph showing the normalized percentage of γH2AX positive Daoy cells co-stained with DAPI nuclear cells.
