Table 2.
Genes related to the immune system and exhibited Semax-induced alteration of expression levels
| Genes related to the immune system (9 genes): | Gene symbol | ENTREZ GENE_ID | Fold change | P-value | |
|---|---|---|---|---|---|
|
3h |
MHC (major histocompatibility class) I and II: |
|
|
|
|
| RT1 class I, CE15 (RT1-CE15), mRNA. |
RT1-CE15 |
414789 |
0.43 |
4.0E-06 |
|
| RT1 class I, M6, gene 2 (RT1-M6-2), mRNA. |
RT1-M6-2 |
365527 |
0.64 |
3.0E-03 |
|
| RT1 class II, locus Db1 (RT1-Db1), mRNA. |
RT1-Db1 |
294270 |
0.55 |
7.6E-04 |
|
| RT1 class II, locus Ba, mRNA. |
RT1-Ba |
309621 |
0.51 |
3.1E-07 |
|
| CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA. |
Cd74 |
25599 |
0.50 |
1.6E-09 |
|
| RT1 class Ia, locus A1, mRNA. |
RT1-A1 |
24973 |
0.50 |
7.6E-10 |
|
| histocompatibility 2, class II antigen E alpha, mRNA. |
H2-Ea |
294269 |
0.49 |
4.1E-10 |
|
|
Others: |
|
|
|
|
|
| Prostaglandin-endoperoxide synthase 2, mRNA. |
Ptgs2/Cox2 |
29527 |
2.00 |
8.3E-34 |
|
| Intercellular adhesion molecule 1, mRNA. |
Icam1 |
25464 |
1.61 |
9.9E-05 |
|
| 24h |
Genes related to the immune system (36 genes): |
|
|
|
|
|
immunoglobulins: |
|
|
|
|
|
| Similar to immunoglobulin heavy chain variable region, mRNA. |
LOC500734 |
500734 |
15.37 |
7.5E-11 |
|
| Similar to immunoglobulin kappa-chain, mRNA. |
LOC500172 |
500172 |
11.57 |
2.1E-34 |
|
| Similar to Immunoglobulin kappa-chain VJ precursor, mRNA. |
LOC500161 |
500161 |
8.31 |
2.1E-34 |
|
| Similar to gamma-2a immunoglobulin heavy chain, mRNA. |
LOC362796 |
362796 |
8.20 |
2.1E-34 |
|
| Similar to immunoglobulin heavy chain variable region, mRNA. |
LOC314492 |
314492 |
6.53 |
2.0E-06 |
|
| Similar to immunoglobulin kappa-chain, mRNA. |
LOC500194 |
500194 |
6.27 |
2.1E-34 |
|
| Similar to Immunoglobulin kappa-chain VJ precursor, mRNA. |
LOC502789 |
502789 |
6.00 |
3.7E-20 |
|
| Similar to immunoglobulin kappa-chain, mRNA. |
LOC502843 |
502843 |
5.74 |
1.7E-19 |
|
| Similar to immunoglobulin kappa-chain, mRNA. |
LOC502797 |
502797 |
5.48 |
5.5E-11 |
|
| Similar to IG kappa-chain V-V region K2 precursor, mRNA. |
LOC500180 |
500180 |
4.67 |
4.8E-08 |
|
| Similar to Igh-1a_predicted protein, mRNA. |
LOC503073 |
503073 |
3.67 |
7.3E-14 |
|
| Similar to NGF-binding Ig light chain, mRNA. |
LOC502820 |
502820 |
3.60 |
5.6E-23 |
|
| Similar to immunoglobulin heavy chain variable region, mRNA. |
LOC500733 |
500733 |
3.08 |
5.3E-14 |
|
| Immunoglobulin heavy chain 1a (serum IgG2a), mRNA. |
Igh-1a |
299352 |
2.97 |
3.5E-26 |
|
| Similar to NGF-binding Ig light chain, mRNA. |
LOC500183 |
500183 |
2.91 |
3.8E-22 |
|
| Similar to Immunoglobulin kappa-chain VJ precursor, mRNA. |
LOC500162 |
500162 |
2.80 |
1.7E-04 |
|
| Similar to immunoglobulin heavy chain variable region, mRNA. |
LOC503070 |
503070 |
2.70 |
1.6E-03 |
|
| Similar to Immunoglobulin kappa-chain VJ precursor, mRNA. |
LOC500163 |
500163 |
2.62 |
8.6E-03 |
|
| Similar to immunoglobulin light chain variable region, mRNA. |
LOC363828 |
363828 |
2.52 |
9.7E-03 |
|
| Similar to IG light chain Vk region Y13-259, mRNA. |
LOC500181 |
500181 |
1.85 |
3.2E-07 |
|
| Similar to Ig kappa light chain precursor, mRNA. |
LOC500177 |
500177 |
1.76 |
3.2E-06 |
|
| Similar to immunoglobulin light chain variable region, mRNA. |
LOC502831 |
502831 |
0.34 |
6.3E-06 |
|
|
Chemokines: |
|
|
|
|
|
| Chemokine (C-X-C motif) ligand 13, mRNA. |
Cxcl13 |
498335 |
4.12 |
1.6E-08 |
|
| Chemokine (C-X-C motif) ligand 9, mRNA. |
Cxcl9 |
246759 |
2.42 |
1.8E-14 |
|
| Chemokine (C-X-C motif) ligand 10, mRNA. |
Cxcl10 |
245920 |
2.32 |
1.9E-03 |
|
| Chemokine (C-C motif) ligand 5, mRNA. |
Ccl5 |
81780 |
1.98 |
6.5E-05 |
|
| Chemokine (C-X-C motif) ligand 11, mRNA. |
Cxcl11 |
305236 |
1.85 |
2.1E-03 |
|
| Chemokine (C-C motif) ligand 7, mRNA. |
Ccl7 |
287561 |
1.78 |
8.3E-04 |
|
| Chemokine (C-C motif) ligand 19, mRNA. |
Ccl19 |
362506 |
1.72 |
3.4E-05 |
|
| Chemokine (C-C motif) ligand 20, mRNA. |
Ccl20 |
29538 |
0.44 |
3.4E-05 |
|
|
MHC (major histocompatibility class) I and II: |
|
|
|
|
|
| RT1 class II, locus Ba, mRNA. |
RT1-Ba |
309621 |
2.28 |
1.5E-15 |
|
| RT1 class I, A3, mRNA. |
RT1-A3 |
309627 |
1.96 |
4.6E-06 |
|
| RT1 class Ia, locus A1, mRNA. |
RT1-A1 |
24973 |
1.94 |
2.8E-11 |
|
| RT1 class I, T24, gene 4, mRNA. |
RT1-149 |
414784 |
1.86 |
3.8E-10 |
|
| Histocompatibility 2, M region locus 10.6, mRNA. |
H2-M10.6 |
414787 |
1.77 |
2.0E-06 |
|
| CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA. | Cd74 | 25599 | 1.63 | 5.3E-06 |
Entrez Gene is NCBI's repository for gene-specific information. In the table, P-values are in the form of an exponential number format.