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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Curr Opin HIV AIDS. 2013 Jul;8(4):255–261. doi: 10.1097/COH.0b013e328361cee8

Table 2.

Similarities between HIV & pathogenic SIV infection of macaques

  1. Chronic progressive infection associated with opportunistic infections and CNS involvement (simian AIDS).

  2. Presence of a minority of “benign” cases (LTNP, EC) associated with low viremia and specific MHC Class-I alleles.

  3. Kinetics of viremia characterized by acute peak and post-peak decline.

  4. Presence of vigorous but ultimately ineffective innate and adaptive immune responses to the virus.

  5. Key pathogenic events include chronic immune activation, mucosal immune dysfunction, microbial translocation, and high levels of infection of central-memory CD4+ T cells.

  6. Virus replication can be suppressed by ART with persisting reservoirs of latently infected cells.