Figure 5. p38 MAPK inactivation attenuates scratch-induced astrogliosis in primary astrocyte cultures.
A. Depicts are representative immunocytochemistry images of GFAP (green), Pp38 (red), DAPI (blue) in primary astrocyte cultures subjected to scratch injury. SB239063, a p38 inhibitor, markedly attenuates GFAP and Pp38 expression. B. Depicts are representative immunocytochemistry images of GFAP, Pp38, and DAPI in primary astrocyte cultures subjected to scratch injury. Scratch induced dramatic increase of Pp38 and GFAP expression in wild type astrocyte cultures which was blocked in primary astrocyte cultures derived from GFAP/p38 knockout mice.