Figure 7. p38 MAPK inactivation inhibits primary astrocyte migration without affecting cell proliferation.
A. Representative transwell assay images demonstrated that primary astrocyte migration was inhibited by p38 MAPK inhibitor, SB239063, and knockout. B. Quantitative analysis of transwell assay. * # p<0.05 vs. control. C. Growth curve assay of primary astrocyte with treatment of SB239063 or control. p38 MAPK inhibition did not affect primary astrocyte proliferation. D & E. Representative cell cycle analysis of primary astrocyte culture at day 1 and day 2, respectively, after treatment of SB239063 or control. p38 MAPK inhibitor did not affect cell cycle of primary astrocyte culture.