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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Brain Res. 2014 Jan 16;1551:45–58. doi: 10.1016/j.brainres.2014.01.013

Figure 9. p38 MAPK knockout attenuated astrogliosis induced by permanent middle cerebral artery occlusion in mice.

Figure 9

A. Depicts are representative GFAP immunohistochemistry images demonstrated that conditional knockout p38 in astrocyte attenuates astrogliosis at 4 days after stroke. B. Quantitative analysis of GFAP positive astrocyte number demonstrated that GFAP/p38 knockout mice have significant fewer astrocytes in the peri-infarct region compared to wild type controls at day 4 after ischemic stroke (*** p<0.001 vs. wild type). C. Quantitative morphometric analysis of GFAP positive astrocytes indicated that GFAP/p38 knockout mice have significantly smaller astrocytes in the peri-infarct region compared to wild type littermates at day 4 after ischemic stroke (*** p<0.001 vs. wild type). D. Depicts are representative Western blots of GFAP, p38 and actin from non-ischemic and ischemic cortex of wild type littermates and GFAP/p38 knockout mice. E. Quantitative analysis of GFAP Western blots demonstrated that GFAP/p38 knockout mice have significantly lower GFAP expression in both ischemic and non-ischemic hemisphere compared to wild type littermates (* p<0.05 vs. wild type non ischemic hemisphere. # p <0.05 vs. wild type ischemic hemisphere).