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. 2014 Apr 15;9(4):e92990. doi: 10.1371/journal.pone.0092990

Table 1. Medication schemes used throughout the study.

Purpose Drug Supplier Application route Dose/Concentration
Induction of anesthesia 2% xylazine hydrochloride (Xylazin) Ceva Sante Animal i.v. bolus 0.1 mg×kg−1
ketamine hydrochloride (Ketamin) Medistar i.v. bolus 4 mg×kg−1
midazolam (Midazolam) Braun Melsungen i.v. bolus 0.2 mg×kg−1
Inhalation anesthesia (during CTV) Isoflurane CP Pharma ventilation 2.0%
oxygen Linde Medical Gases ventilation 40%
Infusion anesthesia (during MRV) Midazolam (Midazolam) Braun Melsungen i.v. infusion 0.1 mg×kg−1×h−1
ketamine hydrochloride (Ketamin) Medistar i.v. infusion 2 mg×kg−1×h−1
1%propofol (Propofol Lipuro) Braun Melsunge i.v. infusion 6 mg×kg−1×h−1
MRV contrast agent gatoderic acid (Dotarem) Guerbet, Cedex i.v. bolus 20 ml per animal
CTV contrast agent Iomeprol (Imeron350) Bracco Imaging i.v. 2 ml×s−1, 90 ml per animal, 80 s delay

Abbreviations: i.v.: intravenous, MRV: magnetic resonance venography, CTV: computed tomography venography.