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. 2014 Apr 15;9(4):e93634. doi: 10.1371/journal.pone.0093634

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© 2014 Abreu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Animals were euthanized at day 5 or 21 post infection and plasma and urine samples were collected for analysis of renal function. Analysis of (A) urinary flow, (B) serum creatinine, (C) blood urea nitrogen (BUN), (D) creatinine clearance (CCr), (E) BUN/serum creatinine ratio, and (F) urinary protein/creatinine (UPC) ratio in different experimental groups as depicted in the figure. *Statistically significant compared with control_5d or control+treated_21d. #Statistically significant compared with control_5d or infected_5d (P<0.05).