Figure 4. Effect of antimalarial treatment on collagen deposition in the renal cortex of mice.

Animals were euthanized on day 5 or 21 post infection (p.i.), perfused, and the kidneys were collected for histologic analysis. Collagen deposition in the renal cortex was visualized using Picrosirius Red stain. Representative photomicrography of noninfected mice (control_5d) (A), 5 days p.i. (infected_5d) (B), noninfected mice that received treatment with antimalarial drugs (control+treated_21d) (C), and infected mice that received treatment with antimalarials (infected+treated_21d) (D) (n = 6 per group). Bar = 20 µm. Collagen deposition is quantified in (E). Values are expressed as a percentage of collagen deposition per area (means ± standard error). *Statistically significant compared with control_5d or control+treated_21d. #Statistically significant compared with control_5d or infected_5d (P<0.05).