Figure 9. The size of the interstitial space is decreased in mice subjected to a second kidney insult.

Animals were euthanized on day 21 post infection (p.i.), perfused, and the kidneys were collected for histologic analysis. The size if the interstitial space in the renal cortex was visualized using periodic acid−Schiff. Representative photomicrographs of (A) control_21d, (B) control+BSA_21d, (C) control+treated+ BSA_21d, (D) infected+treated_21d, and (E) infected+treated+BSA_21d (n = 6 per group). Bar = 20 µm. The size of the interstitial space is quantified in (E). Values are expressed as a percentage of interstitial space per area (means ± standard error) *Statistically significant compared with control_21d. #Statistically significant compared with infected+treated _21d (P<0.05).