Figure 4. Loss of Shp2 causes severe morphological defects at 5 dpf.

Morphology of 5(a) Representative wild-type, (b) ptpn11a-/-, (c) ptpn11b-/- and (d) double homozygous mutant are depicted. (e) The length was measured from nose to tip of tail at the same magnification. Bars show average length of the studied genotypes (n = 10-20). Statistics were determined using a student's t-test; * indicates a p value <0.05.