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. 2014 Apr 15;9(4):e94913. doi: 10.1371/journal.pone.0094913

Figure 1. Pre-receptor regulation of glucocorticoids and TLR expression in human corneal cells.

Figure 1

(A) RT-PCR of PHCEC, PHKF showing expression of the major genes for the pre-receptor regulation of glucocorticoids: 11β-HSD1, 11β-HSD2, H6PD and GR. Macrophages, M1 and M2, also express 11β-HSD1 but not 11β-HSD2. All cell types demonstrate 11β-HSD1 oxo-reductase activity (B), most marked in M1 macrophages. (C) TLR 1–9 induction did not alter 11β-HSD1 activity in either PHCEC or PHKF after stimulation for 16 h.