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. 2014 Apr 15;9(4):e94913. doi: 10.1371/journal.pone.0094913

Figure 2. Human corneal cells respond to TLR stimulation by producing cytokines.

Figure 2

Multiplex bead ELISA analysis (Plex-30) of cytokine production in response to TLR 1–9 stimulation for 16 hours is shown. Cytokines analysed included: IL-1β, IL-1Rα, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p70), IL-13, IL-15, IL-17, Eotaxin, Basic FGF, G-CSF, GM-CSF, IFN-γ, CXCL-10, CCL2, CCL3, CCL4, PDGF-BB, CCL5, TNF-α, VEGF. Induction of a range of cytokines and chemokines was seen after TLR 3 challenge (CCL2, CCL3, CCL4, CCL5, CXCL10, IL1, IFNγ and IFNβ). Values =  Mean+SE, n = 3, Statistical analysis was carried using One-way ANOVA and comparisons were drawn with untreated control Vs TLR stimulated cells. * p<0.05, ** p<0.01, *** p<0.001.