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. 2014 Apr 15;9(4):e95019. doi: 10.1371/journal.pone.0095019

Figure 4. Ox1R antagonist pretreatment reduced caloric intake in both IAM feeding groups.

Figure 4

A: 1st hr total liquid intake for ad libitum water (white column) and additional bottle, containing water (diagonal striped) or 8% fructose (blue column), for control and fructose groups on day 21 of IAM (no injection) and on day 22 of IAM after a 30-min pretreatment with vehicle (2% DMSO and 10% β-cyclodextrin in sterile water; Veh.) or SB-334867 (30 mg/kg, i.p; SB) B: The 1st hr caloric intake, expressed as chow (horizontal striped columns) and 8% fructose (in blue columns) calories. Red lines indicate day 1 intake of water or fructose in panel A and calories in panel B. Mean values ± SEM (n = 6–9/group) *p<0.05 within group 1-way RMANOVA compared to day 21.